Moremi is best visited in the dry season and game viewing is at its peak from July to October, when seasonal pans dry up and the wildlife concentrates on the permanent water. The winter months of May to August can be very cold at night, but pleasantly warm, under clear blue skies, during the day. From October until the rains break in late November or early December, the weather can be extremely hot - both day and night.

Mosquitoes are prevalent throughout the reserve and it is strongly recommended that visitors should take an anti-malarial prophylactic before, during and for four weeks after their visit, especially during the rainy season. Water for drinking should be boiled or chemically treated.